IS Case 342: Chondromyxoid fibroma

Amira Farouga, MD

Imaging Sciences URMC

2009 URMC Imaging Sciences
Publication Date: 2009-11-09


Patient is a 20-year-old female with history of trauma and right elbow pain.


Expansile lytic lesion with septation involving the proximal radius.


Chondromyxoid fibroma is a rare tumor of cartilaginous derivation, characterized by the production of chondroid, fibrous, and myxoid tissues in variable proportion. It occurs predominantly in adolescents and young adults. It has a predilection for the bones of the lower extremities, with preferred sites in the proximal tibia and distal femur.

Its characteristic radiographic picture is that of an eccentrically located radiolucent lesion in the bone, with sclerotic scalloped margin often eroding or ballooning out the cortex. Calcifications are not apparent radiographically. MRI reveals characteristics of most cartilaginous tumors: intermediate to low-signal intensity in T1-weighted and high-signal in T2-weighted sequences.

Commonly, one can observe a characteristic buttress of periosteal new bone formation, in which case a chondromyxoid fibroma may be radiographically indistinguishable from an aneurysmal bone cyst. In unusual location such as in short tubular or flat bones, it may mimic a giant cell tumor.


  1. Fechner RE, Mills SE. Tumors of the bones and joints. AFIP Atlas of Tumor Pathology, Series III. Washington, DC: American Registry of Pathology, 1993.

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