IS Case 362: Liposclerosing myxofibrous tumor

Benita Tamrazi, MD

2009 URMC Imaging Sciences
Publication Date: 2010-03-02


Patient is a 52-year-old male with hip pain.


Intertrochanteric lytic lesion in the proximal femur with sclerotic rim and internal matrix calcifications.


Liposclerosing myxofibrous tumor


Liposclerosing myxofibrous tumor of the bone is a benign fibro-osseous lesion which is histologically characterized by a mixture of lipoma, fibroxanthoma, myxoma, myxofibroma, and fibrous dysplasia. This is often discovered incidentally and radiologically presents as a lytic lesion with sclerotic borders. The lesion may be expansile and is often seen in the femur. It is important to follow the lesion because there is possibility for malignant transformation.


  1. Kransdorf MJ, Murphey MD, Sweet DE. Liposclerosing Myxofibrous tumor: a radiologic-pathologic distinct fibro-osseous lesion of bone with a marked predilection for the intertrochanteric region of the femur. Radiology. 1999 Sep;212(3):693-8. PMID: 10478234

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