IS case 508: Gamna-Gandy bodies
Imaging Sciences URMC 2010
Publication Date: 2010-09-10
Patient is a 54-year-old male with cirrhosis.
Gamna-Gandy bodies are siderotic nodules and/or fibrosiderotic nodules of the spleen. The lesions are originally described in the pathology literature; however, with advances in MRI and US technology, these lesions are more commonly identified. Pathologically, the lesions are comprised of fibrous tissue and elastic fibers with deposition of calcium salts and iron. There is complete disruption of the local splenic architecture. They are seen in cases of splenomegaly due to congestion, including portal hypertension and cirrhosis, sickle cell anemia, and hemochromatosis. Other predisposing conditions include portal vein or splenic vein thrombosis, other hemolytic anemias, leukemia, lymphoma, or paroxysmal nocturnal hemoglobinuria.
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