IS case 508: Gamna-Gandy bodies

Trushar Sarang, MD

University of Rochester


Imaging Sciences URMC 2010
Publication Date: 2010-09-10

History

Patient is a 54-year-old male with cirrhosis.

Findings

Numerous tiny echogenic foci scattered in the spleen with characteristic low MR signal.

Diagnosis

Gamna-Gandy bodies

Discussion

Gamna-Gandy bodies are siderotic nodules and/or fibrosiderotic nodules of the spleen. The lesions are originally described in the pathology literature; however, with advances in MRI and US technology, these lesions are more commonly identified. Pathologically, the lesions are comprised of fibrous tissue and elastic fibers with deposition of calcium salts and iron. There is complete disruption of the local splenic architecture. They are seen in cases of splenomegaly due to congestion, including portal hypertension and cirrhosis, sickle cell anemia, and hemochromatosis. Other predisposing conditions include portal vein or splenic vein thrombosis, other hemolytic anemias, leukemia, lymphoma, or paroxysmal nocturnal hemoglobinuria.

References

  1. Sagoh T, Itoh K, Togashi K, et al. Gamna-Gandy bodies of the spleen: evaluation with MR imaging. Radiology. 1989 Sep;172(3):685-7. PMID: 2672093
  2. Bhatt S, Simon R, Dogra VS. Gamna-Gandy bodies: sonographic features with histopathologic correlation. J Ultrasound Med. 2006 Dec;25(12):1625-9. PMID: 17121963
  3. Dobritz M, Nömayr A, Bautz W, Fellner FA. Gamna-Gandy bodies of the spleen detected with MR imaging: a case report. Magn Reson Imaging. 2001 Nov;19(9):1249-51. PMID: 11755737

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