IS Case 594: Liposclerosing myxofibrous tumor (LSMFT)

Nadia F. Yusaf, MD

Imaging Sciences URMC

Imaging Sciences URMC 2010
Publication Date: 2011-11-17


Patient is an 81-year-old male with two months of right groin pain which is worse with walking and standing.


There is a well-defined lesion in the intertrochanteric region of the femur.


Liposclerosing myxofibrous tumor (LSMFT)


Liposclerosing myxofibrous tumor (LSMFT) is a benign fibro-osseous lesion made of a mixture of histologic elements. The origin is unclear, but it is thought to arise from an involuted lipoma or lipogenic lesion with proliferative change. This lesion is mostly seen within the proximal femur. It is typically indolent with a well-defined, sclerotic margin. On T1, the lesion is homogeneous with signal similar to skeletal muscle. On T2, the lesion is heterogeneous with signal equal to greater than fat. About half of patients present with pain. There is a potential for malignant transformation (10-16%).


  1. Kransdorf MJ, Murphey MD, Sweet DE. Liposclerosing myxofibrous tumor: a radiologic-pathologic-distinct fibro-osseous lesion of bone with a marked predilection for the intertrochanteric region of the femur. Radiology. 1999 Sep;212(3):693-8. PMID: 10478234

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